Hypoallergenic, two phase enzyme capsule. Each capsule contains:
ENTERIC RELEASE PHASE:
Alpha Chymotrypsin………………….2 mg.
GASTRIC RELEASE PHASE:
Superoxide Dismutase……………….25 mcg.
The two phase pH sensitive release of the ingredients in this product is due to its exclusive enteric matrix formulation.
CAUTION: DO NOT TAKE IF STOMACH OR DUODENAL ULCER CONDITION EXISTS.
Two Phase Capsule Allows Both Gastric and Enteric Enzyme Release Because different enzymes are active at different pH levels, the exclusive enteric matrix formulation of Inflamex allows for two phase pH sensitive release of the contents of the capsule, with some of the enzymes being released in the gastric phase and others in the upper intestines or enteric phase.
The single most potent anti-inflammatory substance is alpha chymotrypsin. Inflamex contains 2 mg. of pure alpha chymotrypsin. The addition of trypsin, bromelain, super oxide dismutase (SOD), catalase and other enzymes, makes Inflamex a complete and potent broad spectrum anti-inflammatory supplement effective in the treatment of inflammatory conditions including:
Post Surgical Healing
Dentistry and Oral Surgery
Enzymes Accelerate Drainage and Repair of Inflamed Tissues as Demonstrated in Extensive Clinical Trials
During the inflammatory process, fibrinogen becomes polymerized into fibrin and impairs circulation within the affected tissues. The enzymes in Inflamex will circulate freely until they are impaired by this fibrin blockage. At this point they adhere to the fibrin, depolymerize the occlusion and restore drainage to the inflamed tissue.
Numerous clinical trials have shown enzymes to be both safe and effective in reducing inflammation and swelling whether due to infection or trauma. The following is a brief summary of some of the research.
Treatment of Sciatica Due to Intervertebral Disc Herniation, Rheumatology and Physical Medicine, Vol. XI, No. 1, 1971. “Since orally administered enzymes have very few undesirable side effects, this treatment is suitable for all patients with sciatica due to intervertebral disc herniation. The clinical benefit is presumably due to decrease of inflammatory edema in the nerve root and, in suitable cases, clinical results have been spectacularly good.”
Oral Proteolytic Enzymes in the Treatment of Athletic Injuries: A Double Blind Study, The Pennsylvania Medical Journal, October, 1965. Richard E. Deitrick, M.D., concluded, “Oral enzymes accelerate healing”. As a result of his research he added oral enzymes as a routine to his treatment of athletic injuries. The beneficial effect was not limited to one type of injury, but was seen in a variety of injuries normally encountered in contact sports.
The Use of Proteolytic Enzymes in Sporting Injuries, S.A. Medical Journal, Feb., 1971. In this double blind study of patients sustaining injuries due to accidental trauma in sports, the authors found considerably less bruising, a quicker return to function and fitness to resume play in the proteolytic enzyme treated group. They also noted that the enzymes reduced swelling considerably.
Oral Anti-Inflammatory Enzyme Therapy in Injuries in Professional Football, The Practitioner, April, 1967. “The results reported here confirmed our impressions” that the preparation tested “is effective in reducing time lost due to soft tissue injury in professional football. Doubtless these conclusions are equally valid for similar injuries sustained in other circumstances — sporting, industrial or accidental.” No side effects were observed.
The British Journal of Clinical Practice, September, 1970. A preparation containing trypsin and chymotrypsin was tested on professional football players. Neither the physician nor the patients knew which patients received the enzyme preparation until after the study. “Two separately conducted double blind trials have confirmed the value of proteolytic enzyme therapy in resolving inflammation and associated edema and increasing recovery rates. The overall reduction in recovery time is 1.3 days for hematomata and 2.4 days for sprains — an approximate 27% decrease in recovery time.” Both groups received physical therapy.
Oral Enzyme Tablets in the Treatment of Boxing Injuries, The Practitioner, April, 1967. The author concludes that an enzyme preparation of trypsin and chymotrypsin appears “to be useful both prophylactically and for the treatment of boxing injuries.” The boxers were given either oral enzyme tablets or a placebo one half to one hour before boxing. Among 55 injured boxers who received enzymes, bruising, abrasions, hematomas and sprains cleared up in four to five days and boxing was resumed in one week. Four cuts in the upper lip did not require suturing and cleared up in a week. Four sutured cuts in the orbital region healed completely in two weeks. Among 34 injured boxers who received placebos, bruising, abrasions, hematomas and sprains took two to three weeks to clear. Four sutured cuts took four weeks to heal completely.
Anti-Inflammatory Activity of a Proteolytic Enzyme, Pharmacology, 1980: 21,43-52. Oral proteolytic enzymes were shown to be absorbed in sufficient quantities to bring about anti-inflammatory activity.
Effects of an Oral Enzyme Preparation upon Serum Proteins Associated with Injury in Man, Journal of Medicine, 1974. “The data acquired . . . suggests that by minimizing the initial acute inflammatory response, a possible reduction in development of a more severe, chronic inflammatory process may occur.”
Trypsin in the Treatment of Swellings of the Head and Neck, American Journal of Surgery, December, 1958. “. . . trypsin is of benefit whether the swelling and inflammation is due to infection or to trauma. The impression is also gained that swellings abated more rapidly when trypsin was used than when it was not, thus enhancing surgical repair.”
Inhibition of the Response to Thermal Injury by Oral Proteolytic Enzymes, The Journal of Clinical Pharmacology, Aug. – Sept., 1972. The authors conclude that inflammation resulting from the experimental burn technique used was significantly less in the enzyme treated cases (versus placebo) and that the difference became greater with the elapsed time during the test period.
Gastrointestinal Absorption and Anti-Inflammatory Effect of Bromelain, Japan Journal of Pharmacology, 1972. The data obtained indicates that oral bromelain is absorbable from the gastrointestinal tract and exhibits fairly potent anti-inflammatory activity on the exudative phases. “This inhibitory effect (on edema) was highly significant and almost equivalent to that obtained with hydrocortisone.”
Treatment of Inflammation and Edema with Bromelain, Delaware Medical Journal, 1962. After treating more than 200 patients with bromelain for soft tissue injuries, distortions, fractures, cutaneous infections caused by staphylococci, anal and perianal inflammations and infected wounds after surgery, it was felt the medication had a good effect in 74% of the cases.
Proteolytic Enzymes and Inflammation — Current Status, Exc. Med. Internat. Congr. Ser., 1964. Faster resorption of hematomas and blisters were reported when bromelain was given.
POST SURGICAL HEALING
Therapeutic Value of Oral Proteolytic Enzymes Following Hand Surgery, Archives of Surgery, January, 1969. “The results indicate that enzyme therapy minimizes the edema so frequently seen following hand surgery. In the group treated with enzymes, 21 of 25 patients were considered symptom free on the seventh postoperative day. In the placebo treated group, only 4 of 29 were so classified. Doctors in this randomized, double blind study did not know which patients received the enzymes until after the experiment.
Journal of the American Podiatry Association, July, 1979. C. R. Young, D.P.M., recommends giving proteolytic enzymes 5 days prior to undergoing surgery. The same dose was administered each day while in the hospital and for 5 days following discharge. Dr. Young suggests that better results will be obtained if you begin giving proteolytic enzymes before surgery or trauma, rather than waiting until after an injury has taken place to initiate treatment.
The Use of Proteolytic Enzymes in Reducing Post-Operative Hematomata Associated with Vein Stripping, Lakartidningent, 1971. The authors conclude that proteolytic enzymes “exert a very good effect on the resorption of hematomata.” The group of patients treated with enzymes also “had fewer and less severe postoperative infections.”
The Effect of Bromelain Therapy on Episiotomy Wounds — A Double Blind Controlled Clinical Trial,The Journal of Obstetrics and Gynecology of the British Commonwealth, 1972. This double blind controlled clinical trial showed that “the rate of reduction of edema and bruising was more rapid in the patients on bromelain than in those taking placebo, especially when edema and bruising were severe.”
Three independent double blind trials in obstetrics have shown that proteolytic enzymes are effective following episiotomy. In all three trials there was a lower incidence of pain, swelling and tenderness in the enzyme treated group as compared to the control group Schmnitz & Pavlic, 1961, Obstet. Gynec. 17:260, 1961. Bumgardner & Satuchni, Amer. J. Obstet. Gynec. 92:514, 1965. Soule, Wasserman & I. Burstein, Amer. J. Obstet. Gynec. 95:820, 1966.
Amer. J. Proctol. 13:249, 1962. “A reduction in pain and edema has been observed in rectal surgery and a reduction in the healing time following minor anal-rectal procedures, hemorrhoids and anal fissures.”
DENTISTRY AND ORAL SURGERY
Resolution of Postoperative Swelling Following Oral Surgery, Oral Surgery, 1967. Oral proteolytic enzyme as an aid in the relief of swelling and pain following oral surgery evaluated by a double blind technique in 209 patients were shown to inhibit the development of postoperative edema and swelling. The proteolytic enzymes did not appear to inhibit the development of swelling during the first 24 hours postoperatively. However, there was a 50% increase in the number of patients with moderate or severe swelling during the next 24 hours in the placebo treated patients; whereas, no significant increase occurred among those who received the enzymes.
A Double Blind Crossover Study of a Plant Proteolytic Enzyme in Oral Surgery, Journal of Dental Medicine, 1965. A significant reduction of pain and swelling was seen in 81% of the cases after bromelain administration.